Disseminated intravascular coagulation (DIC) is a syndrome characterised by systemic intravascular activation of coagulation, leading to the widespread deposition of fibrin, with formation of widespread microvascular thrombosis. These microthrombi impair organ perfusion and thus contribute to organ failure. During the coagulation process, consumption of coagulation factors and aggregation of platelets occur resulting in reduced levels of both procoagulant and anticoagulant clotting proteins. Therefore patients with DIC may have both thromboembolic events and hemorrhage.
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